CD4+T Cells

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Condraz23
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CD4+T Cells

Post by Condraz23 » Sat Oct 14, 2006 10:56 pm

Is it possible to use stem cells to grow new CD4+T cells which are immune to the HIV virus and are not rejected from the body?

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Post by Barz » Sun Oct 15, 2006 1:45 am

No. Because the viral RNA retrovirus is run in reverse. The cells are already infected with the virus. It directs the cell to produce a DNA gene sequence from the viral RNA template.

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Dr.Stein
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Post by Dr.Stein » Sun Oct 15, 2006 5:21 am

We have to provide more sophisticated "education" to those stem cells against "smart" HIV :?
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victor
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Post by victor » Sun Oct 15, 2006 12:57 pm

How about mutating those T-cells so that they never have CCR5 receptor. Then HIV won't enter the T-cells..:lol:
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Post by Amrik » Sun Oct 15, 2006 1:55 pm

@victor
the idea is nice...but it is going to be really hard to achieve that, i guess
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Post by sdekivit » Sun Oct 15, 2006 9:28 pm

victor wrote:How about mutating those T-cells so that they never have CCR5 receptor. Then HIV won't enter the T-cells..:lol:


what physiological effects are due to absence of the CCR5 ?

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Post by Dr.Stein » Mon Oct 16, 2006 11:01 am

Well, if engineering CD4+ is hard, I think we need to educate macrophage much better. It helps HIV to meet CD4+ :twisted:
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victor
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Post by victor » Mon Oct 16, 2006 11:46 am

@Dr.Stein
hmm....I think that macrophage also act like innocent cells when it meets with HIV. Um...like commonly cells, HIV will enter macrophage via CXCR4 receptor, so how could we educate those macrophage?

@sdekivit
In my book (JMAMMB), it discusses about HIV profile and it's written that a patient with mutation on the T-Cell (CCR5 receptor) is immune to AIDS. Then the book doesn't write anything about the bad effect of this mutation.

JMAMMB = Jawetz, Melnick & Adelberg's Medical Microbiology. Written By Geo F. Brooks, Janet S. Mutel, and friends...:mrgreen:
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Post by Dr.Stein » Tue Oct 17, 2006 3:24 am

victor wrote:@Dr.Stein
hmm....I think that macrophage also act like innocent cells when it meets with HIV. Um...like commonly cells, HIV will enter macrophage via CXCR4 receptor, so how could we educate those macrophage?

That's it. It should not be that innocent! :twisted:
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