Hexokinase genes

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Hexokinase genes

Post by tetedupet » Fri Oct 13, 2006 2:22 pm

Q: How many HEXOKINASE genes are there in humans?

I'm having some problems with this question - I went onto Enterez-gene and searched for "hexokinase" restricting the search to Homo sapien and got the following output:

1: GCK glucokinase (hexo... [GeneID: 2645]

2: GCKR glucokinase (hexo... [GeneID: 2646]

3: HK1 hexokinase 1 [GeneID: 3098]

4: HK3 hexokinase 3 (whi... [GeneID: 3101]

5: HK2 hexokinase 2 [GeneID: 3099]

Which, is indeed 5 genes, but... the first 2 are glucokinases which are also hexokinases, but in the question hexokinase is in capitals... so I'm not sure if to include the first 2. Also, if I get information on CGK, it says:

Official Full Name
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)

So does this mean it's only present in people with diabetes or what?

If I click the GCKR gene, it says

Official Full Name
glucokinase (hexokinase 4) regulator

Does this mean it's just a regulator and not a hexokinase? And why would there be more than one gene for hexokinase anyway?

Any help would be much appreciated.

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Joined: Thu Oct 19, 2006 10:40 pm

Post by b » Thu Oct 19, 2006 10:44 pm

i also that the same problem. i have the feeling we are probably doing the same work.
are you from uni of edinburgh, bio sciences?
i will try finding the answer and when i do i will get in touch.

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Joined: Wed Jan 04, 2006 4:48 am

Post by Ultrashogun » Sun Oct 22, 2006 3:03 pm

As far as I know glucokinase is the hexokinase of the liver cells. It has a higher Km and is regulated a little differently I think.

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Joined: Fri Oct 27, 2006 2:35 pm

Post by elsie » Fri Oct 27, 2006 2:36 pm

hah yeah i'm edinburgh uni too.. Shall we try and get some kind of help/discussion session set up for this?

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