Discussion of all aspects of cellular structure, physiology and communication.

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Post by moltek2 » Sun May 01, 2005 10:47 am

What role(s) does cyclic AMP play in intracellular messaging?
How is cyclicAMP switched on and turned off,
and are there other molecules that mimic its behaviour?

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Post by tbrahim » Mon May 02, 2005 12:21 am

cAMP can affect the CREB(cAmp response element binding protein) in the cell nucleus to upreguate transciption of certain enzymes or cell protiens. cAMP can also bing to ion channels to regualte channel opening lifetime or just as a intracellular ligand.It has been implicated with the molecular physiology of drug addiction. It is usually turned off buy PDE(phosphodiesterase) which returns it to AMP. Some toxins and drugs are targeted towards PDE. AS for other intracellular messengers, the list is large and can include Calcium and cGMP.
Pharmacology, molecular cell biology, psychiatry,neurobiology,pathology,anthropology.These are fun subject areas.Get funking Krunk!

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Post by ewokgod » Sun Jun 05, 2005 8:39 am

cAMP as a second messenger also responds to ADH in the kidney in order to control water balance.
increased ADH implies:
- increased activity of adenyl cyclase.
- increased cAMP level in cell.
- activates various phosphokinases.
- causes contraction of microfilaments.
- aqueporin is inserted into kidney luminal membrane.
- water is absorbed.
- ADH comes of receptor and destroyed.
- cAMP level falls.
- aqueporin goes back into the cell.

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