Mutations in TCR and BCR problem

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myd88
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Mutations in TCR and BCR problem

Post by myd88 » Tue Sep 26, 2006 11:45 pm

I think this is relatively simple ..jus wanted to put it out there.

Suppose a strain of mouse contains mutations in the ITAM residues of the BCR-associated signaling molecules Igα and Igβ, as well as mutations in the ITAM residues of the TCR-associated CD3 chains.

If this strain of mouse is infected by a pathogen, how would the ADAPTIVE immune response affected by these mutations?

I am thinking along the lines that ....Since pathogen can't bind to B cells, there's no activation of proliferation of T cells nor the signalling cascade through BCR. Hence, no adaptive immune response can take place nor will there be any memory for reinfection?? any other suggestions?

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