DNA stable in DMSO-H2O system?

[ahkian82]

DNA stable in DMSO-H2O system?

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Post by ahkian82 » Tue Aug 08, 2006 3:22 am

In the effort of determining the binding properties of some inorganic complexes with calf thymus DNA, i have come across a solubility problem. Some of the complexes are barely soluble in aqueous solution. I noticed that DMSO can be used to aid dissolution, but how stable is the DNA in this kind of mix solvent system? To what extent, or how much DMSO can be added before the denaturation (or strand separation ??) of the ds-calf thymus DNA?

Thanks.

ahkian82