The other side of DNA?

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

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MrMistery
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Post by MrMistery » Sat Jul 22, 2006 8:26 pm

like it was said before, the terms sense strand and non-sense strand only have a meaning about one gene. The same strand can be coding for one gene and non-coding for another gene. This is an important gene expression system in eukaryotes.
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razor4
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Antiparallel overlapping genes

Post by razor4 » Mon Jul 24, 2006 10:28 am

It is definitely possible that the 'sense' sequences of two genes, located on opposite strands of DNA, overlap. These are called 'antiparallel overlapping genes'. It is relatively rare, however, that the two antiparallel genes overlap in their protein-coding sequence.
(Fukuda, Y., Nakayama, Y., and Tomita, M. 2003. On dynamics of overlapping genes in bacterial genomes. Gene 323: 181-187)
Oftentimes, in the human genome at least, one of the two genes in the pair is NOT a protein-coding gene (meaning that the functional gene product is the RNA) .
(Chen J. et al., 2004. Over 20% of human transcripts might form sense–antisense pairs, Nucleic Acids Res. 32: 4812– 4820.

sdekivit
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Post by sdekivit » Mon Jul 24, 2006 8:14 pm

another source about the organization of genes in the genome: Human Molecular Genetics 3 by Strachan & Read.

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Post by CurlyQe » Mon Jul 24, 2006 10:16 pm

MrMistery wrote:like it was said before, the terms sense strand and non-sense strand only have a meaning about one gene. The same strand can be coding for one gene and non-coding for another gene. This is an important gene expression system in eukaryotes.


oh! so IF there was a gene that needed coding/expressed on the other strand, that strand would become the "sense" strand and the other would become the nonsense strand?
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Post by sdekivit » Tue Jul 25, 2006 9:47 am

that's exactly the point made here :)

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