Discussion of all aspects of cellular structure, physiology and communication.
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I am having trouble differentiating between the ER lumen and cytosol. Indeed, the ER is contguous with the nucleus and phospholipid bilayer in many eukaryotic cells. Anyways, my text states that the ER "separates the cytosol from the ER lumen (the "extracellular" fluid side of the ER)." This information baffles me. I thought the cytosol was the extracellular fluid side of the ER. After all, my understanding is that the phospholipid bilayer encompasses the cytosol, which encompasses the ER, which would encompass the ER lumen. If I were correct, then the ER lumen would be the intracellular side of the ER. But I'm incorrect, because the ER lumen is, as the text states, the extracellular side of the ER. Someone please explain.
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