Endoplasmic Reticulum funtion?

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student12
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Endoplasmic Reticulum funtion?

Post by student12 » Sun May 14, 2006 12:53 pm

After the ribosomes synthesise polypeptides they pass into the lumen of the ER where they can be added sugar molecules to make glycoproteins.

Question: Is this also where polypeptides are modified for example being cleaved by protease to form functional proteins?
Also where chaperone proteins help the protein fold correctly into its tertiary structure?

rg
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Post by rg » Mon May 15, 2006 7:29 am

the final processing to protiens(like gycosylation etc.) is done in golgi complex....ER transports synthesised substances...but they may also participate in works like detoxification in liver by smooth ER.....chaperones do this possibly in the cytoplasm....

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LilKim
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Post by LilKim » Mon May 15, 2006 12:47 pm

chaperones are present in the ER... and initially they help keep protiens unfolded... and eventually they help fold the proteins at the appropriate time (at a certain point during translation... or after translation)

However, many proteins are folded before the get to the golgi.

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Post by jacob mack » Tue Oct 03, 2006 6:45 pm

LilKim wrote:chaperones are present in the ER... and initially they help keep protiens unfolded... and eventually they help fold the proteins at the appropriate time (at a certain point during translation... or after translation)

However, many proteins are folded before the get to the golgi.



That is true, ER helps transport necessary products to the cell membrane as it is connected to it; (e.g. glycoproteins ect...) and so chaperones would be necessary in some cases of pre-- ER transport to facilitate modification for immeduate use.

sporkius
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Post by sporkius » Wed Oct 04, 2006 2:29 am

http://www.projectuniv.org/Biology/GeneralBiology1.htm

I wrote this a couple weeks ago. You might want to look at it. It covers everything in this post and more. Hope it will help.

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MrMistery
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Post by MrMistery » Wed Oct 04, 2006 5:53 pm

a little too basic and contains some wrong info.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

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