prions

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pedro21101
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prions

Post by pedro21101 » Mon Apr 17, 2006 9:17 pm

Hello

Id like to know if prions in all animals which it affects, has the same sequence of amino acids, if it is still the same molecule. :roll:
Thanks

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LilKim
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Post by LilKim » Mon Apr 17, 2006 10:11 pm

A prion is a protien that has folded incorrectly... once it folded incorrectly.. it can influence other proteins (with the same sequence as the first one) to fold incorrectly too..

The problem is that these proteins don't function corretly.. they then aggregate and cause the cells to die..

As far as the same sequece? Hmm.. I'm not sure... although I think that there may be some degree of similarity (some similar motifs) but the mad cow prion.. and the S. Cervisae prions are different proteins altogether.

- KIM

pedro21101
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Post by pedro21101 » Tue Apr 18, 2006 11:23 am

Ok, that even says more than i wanted to know...thanks thanks thanks.
Hmmm..they are probably not of the same origin. :roll:

Ultrashogun
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Post by Ultrashogun » Sat Apr 29, 2006 9:37 am

Im pretty sure its the same sequence. If not, how could PrPc fold to PrPsc with no actual change in sequence?

It must be a local minimum in the G of the folding process.

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Post by kiekyon » Sat Apr 29, 2006 12:06 pm

same sequence, just wrongly folded :x

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