Substitution rate in RNA viruses

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HELISA
Death Adder
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Substitution rate in RNA viruses

Post by HELISA » Sat Apr 15, 2006 4:03 pm

Hi,
I've been reading an article about RNA viruses and I found the information that substitution rate in RNA viruses decline with increasing genome size. Why is that? I thought that, if a virus has a bigger genome it should accumulate more mutations...
Any idea?
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2810712
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Post by 2810712 » Tue Apr 18, 2006 2:57 pm

I think the 'rate' is the fraction of sites substituted. So, in a larger genome , the no. of mutations may be high but the fraction still may be lesser than some other smaller viral genome...
May be , due to introduction of highly adapted and constant new sequences the total fraction of mutations has become lesser...just a guess...have to check for it.


Nice topic HELISA, just sweet like science!



hrushikesh

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