insulin

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gumshoes_15
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insulin

Post by gumshoes_15 » Mon Mar 13, 2006 11:21 pm

Why is insulin nbot taken in pill form?

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mith
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Post by mith » Tue Mar 14, 2006 12:18 am

It might be digested....
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Khaiy
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Post by Khaiy » Tue Mar 14, 2006 12:50 am

Isulin needs to be in the bloodstream to have any effect. It could be digested, like mithrilhack said, and even if it weren't ingesting it would mean a considerable wait until it could enter the bloodstream. Injections are immediate, which allow for more precise control over a person's blood sugar level.

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cardiorrhexis
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Post by cardiorrhexis » Tue Mar 14, 2006 1:02 am

There ARE oral hypoglycemics....

http://www.umassmed.edu/diabeteshandbook/chap09.htm

However, insulin is not a very stable hormone when administered orally. It is deteriorated by digestive enzymes before absorption can occur.
I believe pharmaceutical companies have been trying to make one for years....

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VeenaandNivyah
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Post by VeenaandNivyah » Tue Mar 14, 2006 2:09 pm

Why is that the blood sugar level is dependent upon the insulin???
VeenaandNivyah

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Poison
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Post by Poison » Tue Mar 14, 2006 5:31 pm

Insulin stimulates the synthesis of glycogen from glucose.


And about not taking in pill form: It will be digested like the meat you eat. :)
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MrMistery
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Post by MrMistery » Tue Mar 14, 2006 7:43 pm

I agree about the digestion part: Insulin, a peptidic hormone with 51 aminoacids with a rather loose tertiary conformation, will easily denaturate in the pH=2 environment of the stomach and get digested by pepsine, tripsine, chemotripisine, erepsine etc.

What i do not agree about is that the reason is the stimulation of glicogen synthesis. Sure, it is true. Insulin does play that role. But the main reason is that insulin play a key role in the uptake of glucose by cells. That is one of the reasons why diabethics use fructose, it enters the cell by facilitated difusion, insulin or no insulin.
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Poison
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Post by Poison » Tue Mar 14, 2006 8:04 pm

Yes it provides cells to get glucose but you can not hold glucose as glucose for a long time in the cell. You should use for ATp synthesis or macromolecule synthesis. The things you and I say are basically same, aren't they?
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MrMistery
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Post by MrMistery » Wed Mar 15, 2006 6:44 pm

I guess they are.. I just had a wider picture... I never said you are wrong(this time :D )
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