Oestrogen receptors
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Oestrogen receptors
In what ways do oestrogen receptors differ from insulin receptors?
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MrMistery
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My homework question sense is tingling. But i'll answer anyway.
The receptors for these 2 hormones differ radically, in both their structure but more important, location.
Insulin is a proteic hormone, therefor hidrophilic. It can not diffuse through the plasma membrane so it uses a special receptor on the plasma membrane to initiate different signal transduction pathways.
Estrogen, on the other hand, is a steroid hormone, that can easily cross the plasma membrane by diffusion. It's receptor is located within the cytoplasm. After it binds to it's receptor it enters the nucleus and acts as a promotor for various genes in various cells.
Now that i have given the answer, tell me, was it a homwork question?
The receptors for these 2 hormones differ radically, in both their structure but more important, location.
Insulin is a proteic hormone, therefor hidrophilic. It can not diffuse through the plasma membrane so it uses a special receptor on the plasma membrane to initiate different signal transduction pathways.
Estrogen, on the other hand, is a steroid hormone, that can easily cross the plasma membrane by diffusion. It's receptor is located within the cytoplasm. After it binds to it's receptor it enters the nucleus and acts as a promotor for various genes in various cells.
Now that i have given the answer, tell me, was it a homwork question?
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter
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Dr.Stein
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Re: Oestrogen receptors
fran008 wrote:In what ways do oestrogen receptors differ from insulin receptors?
Location.
As a steroid hormne, receptor for estrogen locates in cytosol and nucleus.
As a peptide hormone, receptor for insuli locates in plasma membrane.
Thus, the mechanism of hormone-binding by target cell and how the hormone takes effect on that cell is quitely different.
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