Oestrogen receptors

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fran008
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Oestrogen receptors

Post by fran008 » Wed Mar 08, 2006 12:35 pm

In what ways do oestrogen receptors differ from insulin receptors?

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Poison
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Post by Poison » Wed Mar 08, 2006 5:17 pm

Receptors are specific. Is that what ou want to know?
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MrMistery
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Post by MrMistery » Wed Mar 08, 2006 6:21 pm

My homework question sense is tingling. But i'll answer anyway.
The receptors for these 2 hormones differ radically, in both their structure but more important, location.
Insulin is a proteic hormone, therefor hidrophilic. It can not diffuse through the plasma membrane so it uses a special receptor on the plasma membrane to initiate different signal transduction pathways.
Estrogen, on the other hand, is a steroid hormone, that can easily cross the plasma membrane by diffusion. It's receptor is located within the cytoplasm. After it binds to it's receptor it enters the nucleus and acts as a promotor for various genes in various cells.

Now that i have given the answer, tell me, was it a homwork question?
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fran008
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Post by fran008 » Wed Mar 08, 2006 10:12 pm

Of what significance is this? Does it make the overall effect of oestrogen faster? Now this is no hw question even if the previous one was...sorry my appologies!

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Dr.Stein
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Re: Oestrogen receptors

Post by Dr.Stein » Thu Mar 09, 2006 5:28 am

fran008 wrote:In what ways do oestrogen receptors differ from insulin receptors?

Location.
As a steroid hormne, receptor for estrogen locates in cytosol and nucleus.
As a peptide hormone, receptor for insuli locates in plasma membrane.
Thus, the mechanism of hormone-binding by target cell and how the hormone takes effect on that cell is quitely different.
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