If there is a greater amount of activated T lymphocytes, doe

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
Alexmopan
Garter
Garter
Posts: 1
Joined: Mon Sep 04, 2017 7:50 pm

If there is a greater amount of activated T lymphocytes, doe

Post by Alexmopan » Mon Sep 04, 2017 8:55 pm

Molecular analysis of human tumors demonstrated that cell cycle regulators have frequently mutated in human malignancies, highlighting the prominence in maintaining cell cycle involvement in the prevention of human cancer. Cell cycle regulation is a markedly complex process with many control phases and one of these multiple mechanisms involves the degradation of CDK inhibitors (CKIs) as p27Kip1 by the ubiquitin proteasome system (UPS). Cks1 is a 9 kDa protein that is frequently overexpressed in several tumor subtypes and has pleiotropic functions in cell cycle progression, this protein is a regulator of cyclin-dependent protein kinase, the same component on which the inhibitory protein of the CDKN1B cell cycle encoded by the p27Kip1 gene also depends.
It has been shown that IL-2 protein causes a reduction in p27Kip1 levels. This protein is produced by activated T lymphocytes. My question is whether increasing IL-2 protein production could decrease production of the CDKN1B protein synthesized by p27Kip1, since a mutation in this gene could lead to loss of control over the cell cycle, causing uncontrolled cell proliferation.

Lucille
Garter
Garter
Posts: 1
Joined: Fri Mar 02, 2018 5:27 pm

Re: If there is a greater amount of activated T lymphocytes, doe

Post by Lucille » Fri Mar 02, 2018 5:30 pm

You are asking about what will happen when we have a larger military, and defense. Of course, it is a very good thing for our immune system to have a good defense. It is mentioned in a best essay writing service that more white blood cells our body will have, the more it can defend against the diseases. Thanks a lot for sharing such information with others.

claudepa
Death Adder
Death Adder
Posts: 81
Joined: Tue Nov 03, 2015 12:43 pm

Re: If there is a greater amount of activated T lymphocytes, doe

Post by claudepa » Fri Mar 02, 2018 6:48 pm

I am afraid it is not so simple. In cancer immunotherapy there the good lymphocytes, cytotoxic T lymphocytes but there are also the bad ones, the regulatory T lymphocytes (TREGS) which prevent the action of T lymphocytes. So in cancer immunotherapy the therapy consists in having more cytotxic T lymphocytes and less TREGS.

Post Reply

Who is online

Users browsing this forum: No registered users and 5 guests