Immunology

Debate and discussion of any biological questions not pertaining to a particular topic.

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TrevorL
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Immunology

Post by TrevorL » Fri Jan 27, 2006 10:50 am

Help, has anyone got a definition for conserved epitope. Trevor.

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Dr.Stein
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Post by Dr.Stein » Fri Jan 27, 2006 11:08 am

Epitope that is conserved in order not to undergo molecular change, because once it changes, it will not work properly and can harmfull the system. For example epitope of T-helper cell, the epitope is highly conserved because this cell functions to activate B-cell or macrophage after being presented by APC, if its epitope changes, another cells cannot interact with it anymore, means that there will be no immune response.

Epitope of pathogens also conserved so when reinfection happens again, immunological memory will remember. Some pathogens that capable to change their epitope periodically is a nightmare for the immune system.
Last edited by Dr.Stein on Fri Jan 27, 2006 11:14 am, edited 1 time in total.
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TrevorL
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Post by TrevorL » Fri Jan 27, 2006 11:12 am

Thanks Dr Stein, you're a life saver, Trevor.

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Post by Dr.Stein » Fri Jan 27, 2006 11:17 am

No problem. I hope I give you the proper definition, because so far that IS all I know ;)
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