Why cancer cells change Gln metabolism?

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whbio
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Why cancer cells change Gln metabolism?

Post by whbio » Thu Jul 21, 2016 9:22 am

Colon cancer is one of the most popular cancers both in males and females. A recent research demonstrated that some colon cancer cells can alter the metabolism of glutamine (Gln), a non-essential amino acid critical for various biochemical functions. Although it's known that a lot of cancers depend on this amino acid to survive, the underlying mechanism is still in debate.

claudepa
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Re: Why cancer cells change Gln metabolism?

Post by claudepa » Tue Aug 02, 2016 2:24 pm

Can you graft human colon cancer cells to nude or PDX mice and feed the mice without glutamine ? will the mice survive? will the tumor shrink? A leukemia, I do not remember which one, depends on asparagine and tumor cells are not able to synthetize asparagine. So it is efficiently treated in patients with asparaginase since a long time ago.

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