peripheral and integral protein

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Mr.Smoke
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peripheral and integral protein

Post by Mr.Smoke » Sat Jan 21, 2006 6:28 pm

Dear Friends,
I need your help in order to know about peripheral and integral protein.
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Poison
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Post by Poison » Sat Jan 21, 2006 7:28 pm

What do you want to know about them?
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MrMistery
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Post by MrMistery » Sun Jan 22, 2006 10:27 am

peripheral proteins are soluble proteins which are attached by one way or another to the cellular membrane. they do not cross the cell membrane, but are attached to one side.
integral proteins cross the cell membrane and have a hidrophobic component(inside the membrane) and hidrophilic component(outside the membrane). Also there are some aminoacids present when the protein enters the membrane that keep it in place, and prevent it from sliding.
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Dr.Stein
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Post by Dr.Stein » Sun Jan 22, 2006 12:44 pm

Need a figure? ;)
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opuntia
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Post by opuntia » Sun Jan 22, 2006 12:49 pm

A picture to go with the explanation could make it easier to understand...so i think we need one :wink:
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MrMistery
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Post by MrMistery » Sun Jan 22, 2006 1:22 pm

Here's a nice schematic picture. I got more beautiful ones, bu this seemed the best for understanding
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victor
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Post by victor » Sun Jan 22, 2006 1:26 pm

haha...I'll say the words that Dr.Stein hate.....the integral protein is alpha-helixed..:lol:
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Post by MrMistery » Sun Jan 22, 2006 1:46 pm

alpha-helixed? Is that a word? :lol:
And it is not even correct. Generally it is organised by alpha-helix. But sometimes it takes the shape of beta-barrels(like in the protein porin, in the inner mithocondrial membrane). With alpha-helix you need at least 7-8 aminoacids to cross the membrane, with beta-barrels it can be done with fewer=> molecular economy.
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victor
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Post by victor » Sun Jan 22, 2006 1:53 pm

Yup, she doesn't really like biochem..:lol:
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Post by Mr.Smoke » Mon Jan 23, 2006 6:02 pm

Thanks, for co-operation It really help me alot in understanding integral and peripheral protein in short cut.
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Dr.Stein
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Post by Dr.Stein » Tue Jan 24, 2006 7:16 am

Aww Victor, it seems that you take my four Aces now :oops: :oops: :lol:

Yeah, I only got C for biochem because of the alpha-helix and the gangs aargh grrrrr :twisted: :( :lol: I admit that I am soo bad at "pure" biochem, I prefer "applied" biochem and can understand it much better, for instance: the biosynthesis of steroid hormones, the diversity of MHC, etc. etc... That's much more obvious rather than alpha-helix, beta-conformation, etc. etc. pfff :roll: :lol:
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