Nature Communications: Who defines lifespan ?

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
today11
Garter
Garter
Posts: 1
Joined: Mon May 11, 2015 6:23 am

Nature Communications: Who defines lifespan ?

Post by today11 » Tue May 12, 2015 7:43 am

Microtubule-targeting agents (MTAs) in anticancer therapy is because they can cause cell death on extended mitotic arrest, the machinery of controlling mitotic arrest is well defined, while the components handling cell death and factors associated in the networks are still not understood very well. Recently, scientists aimed to systematically assess the relative contribution of individual BCL2 family members to cell death initiation on MTA ( BI 2536 from [url][/url] http://www.selleckchem.com/products/BI-2536.html [url][/url]) treatment with single cell resolution. Our work shows that BCL2 and BCLX phosphorylation represents a priming event in mitotic cell death that is triggered by NOXA-dependent MCL1 degradation. The MCL1 decay allows in turn BIM-dependent cell death.

See more details :http://www.nature.com/ncomms/2015/150429/ncomms7891/full/ncomms7891.html

Post Reply

Who is online

Users browsing this forum: No registered users and 7 guests