About Polyclonal Antibodies

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Steven2015
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About Polyclonal Antibodies

Post by Steven2015 » Wed Apr 22, 2015 7:41 am

The immune response to an antigen generally involves the activation of multiple B-cells all of which target a specific epitope on that antigen. As a result a large number of antibodies are produced with different specificities and epitope affinities and these are known as polyclonal antibodies.
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Polyclonal antibodies recognize multiple epitopes on any one antigen. Serum obtained will contain a heterogenous complex mixture of antibodies of different affinity. They are made up mainly of IgG subclass and peptide immunogens are often used to generate polyclonal antibodies that target unique epitopes, especially for protein families of high homology. Most polyclonals are goat or rabbit polyclonals and there are also other species such as mouse, rat, chicken.

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