Steroid Hormone Entry

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
User avatar
cytochromeP
Death Adder
Death Adder
Posts: 73
Joined: Wed Apr 06, 2005 2:17 pm
Location: Third Rock From The Sun
Contact:

Steroid Hormone Entry

Post by cytochromeP » Tue Jan 10, 2006 3:30 am

A steroid hormone must pass through the lipid bilayer. How would a steroid hormone break its stable interaction with the bilayer to enter a region which is aqueous?
A sub-question to this would be:
Consider an intermediate state in steroid hormone entry when it is exactly within the bilayer. Now, shouldn't the probablity that it exits the bilayer on either side (into the cell or outside the cell) be equal for both sides? i.e. should one expect only 50% of steroid molecules that enter the bilyer to actually enter the cell and the remaining 50% to 'fall out' ?
Know thyself.

User avatar
Dr.Stein
King Cobra
King Cobra
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia
Contact:

Post by Dr.Stein » Tue Jan 10, 2006 10:49 am

Have you ever heard a thing called "receptor"? ;)

Yes, steroid hormones is hydrophobic that cannot easily being in aqueous region. After diffusing via lipid bilayer, steroid hormones will be bound to their cytosolic receptor, which is a protein. You know protein is hydrophilic. Say this receptor acts as a 'vehicle' for steroid hormone to move to nucleus and take effect over there by changing the DNA expression approprately as the nature of steroid.
Image

Post Reply

Who is online

Users browsing this forum: Google [Bot], kakanai0 and 4 guests