A question about thalassemia

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opuntia
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A question about thalassemia

Post by opuntia » Fri Dec 30, 2005 3:35 pm

What would happen if an alpha thalassemia carrier and a beta thalassemia carrier have a child? Will the child be able to produce the haemoglobin efficiently or will the child have a deficit in the production of haemoglobin?

Can anyone discuss anything related to it?
Thanks in advance,
Opuntia.
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Post by sdekivit » Fri Dec 30, 2005 6:37 pm

it could be, since the parents are carriers, there is a chance of a healthy child according to genetics. rwcall, that alpha and beta thalssemia are different mutations on different chromosomes.

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Post by opuntia » Sat Dec 31, 2005 8:27 am

Thanks for the help, sdekivit :D

Well, i know that a cross between two α-thalassemia carriers would have have 25% chance of producing a normal child, 25% of producing an α-thalassemia major child and 50% of producing α-thalassemia carrier child. And also a cross between two β-thalassemia carriers would have 25% chance of producing a normal child, 25% of producing an β-thalassemia major child and 50% of producing β-thalassemia carrier child.
But if a cross between an α-thalassemia carrier and a β-thalassemia carrier, i know that they have 25% of producing an α-thalassemia carrier, 25% of producing a β-thalassemia carrier, 25% of producing a normal child, and now comes my actual question, but what about the remaining 25%?
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Post by sdekivit » Sat Dec 31, 2005 11:18 am

opuntia wrote:Thanks for the help, sdekivit :D

Well, i know that a cross between two α-thalassemia carriers would have have 25% chance of producing a normal child, 25% of producing an α-thalassemia major child and 50% of producing α-thalassemia carrier child. And also a cross between two β-thalassemia carriers would have 25% chance of producing a normal child, 25% of producing an β-thalassemia major child and 50% of producing β-thalassemia carrier child.
But if a cross between an α-thalassemia carrier and a β-thalassemia carrier, i know that they have 25% of producing an α-thalassemia carrier, 25% of producing a β-thalassemia carrier, 25% of producing a normal child, and now comes my actual question, but what about the remaining 25%?


use the rules for the dihybrid cross-breeding. The mutations occur at different alleles on different chromosomes, so they are uncoupled.

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Post by victor » Sun Jan 01, 2006 11:51 am

Um, do you know how to detect someone become thallasemia carrier or not from the crossing table?? Both of my parents are thallasemia carrier and my younger sister gets major alpha-thallasemia....but, I wonder what about me? a carrier or normal???
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Post by opuntia » Sun Jan 01, 2006 3:47 pm

victor wrote:Um, do you know how to detect someone become thallasemia carrier or not from the crossing table?? Both of my parents are thallasemia carrier and my younger sister gets major alpha-thallasemia....but, I wonder what about me? a carrier or normal???


Do you mean the genetic diagram?
well, i won't say that the diagram always is 100% efficient :twisted:
To make sure if you are a carrier or not, you can test for thalassemia...i did it a few days ago. 8) You can either be a carrier or normal (not both :lol: )
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Post by victor » Wed Jan 04, 2006 1:33 pm

But I think for now, it's not a necessary yet.....just wait till I want to get married....hahaha
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