what happen to the rest??

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MrMistery
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Post by MrMistery » Sat Jan 07, 2006 8:03 pm

You're right on that one, there isno dirrect connection between them as CoA is naturally in it's CoA-SH form. I simply don't know what i was thinking... Must be from the short time until starting of school.
However, if you put citrate inside the mithocondria it MAY turn into oxaloacetate via Krebs cycle. This means that after you drink orange jiuce for a few months your mithocondrail matrix is oversaturated by oxaloacetate molecules. This makes the pathway highly unlikely since evolution has selected the optimum quantity of acids to be present inside the mithocondrial matrix for it to function at maximum capacity.
Second of all, and this is just another stupid hypothisys that came to my mind now, how does the cell regulate the number of enzimes needed to turn one Krebs cycle intermediate into another... I bet the regulation involves number of glucose molecules ;)
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victor
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Post by victor » Sun Jan 08, 2006 12:00 pm

Hm...quite reasonable...:lol:
hey this is what I think, citrate will undergo Krebs and turn into oxaloacetate. If this thing is happen highly frequented, then there'll be an oxaloacetate saturation. To make it stable, I think our body will convert some glycogens and fats into glucose and send it into matrix of mitochondria....
I can think that'll happen because as you said Andrew, OJ has a little citrate acid....so it will not affect much on us...
I also read that citrate acid more than 70% can result pH lower than 4.65 which is dangerous for our stomach...:mrgreen:
So, don't try this at home (I mean drinking citrate acid 70%)
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MrMistery
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Post by MrMistery » Sun Jan 08, 2006 2:23 pm

pH under 4.65 dangerous for our stomach?? HAHAHAHA Coca-cola ahs an average pH=2,71.
So basically what you are saying is that the body, afetr having this huge amount of oxaloacetic acid in it's mithocondria will keep sending glucose there until when? at the end the glucose becomes oxaloacetic acid again. It will demand too much energy and not solve the problem. Enlighten me, what would the point of such a pathway be?
Again i say, i think the body could easily make more oxaloacetic acid to increase number of krebs cycle intermediates but as i said, i think evolution has chosen the OPTIMUM value.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

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victor
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Post by victor » Tue Jan 10, 2006 12:03 pm

Oops, sorry...I'll change that...I think it's no good for our tongue..:oops:
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