drugs and heart rate

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countyclare
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drugs and heart rate

Post by countyclare » Mon Dec 12, 2005 5:06 am

Does anyone know of a good journal article that talks about the mechanisms and subsequent effects of ethanol and caffeine (separately) on heart rate? I know ethanol decreases heart rate and caffeine increases, but how is what I am unsure of. Thanks in advance to anyone who can help me!!! :o
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chicoguardian
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Post by chicoguardian » Mon Dec 12, 2005 12:56 pm

try this site, I think think it should have plentful enough info that you will need... http://kidshealth.org/teen/drug_alcohol ... drugs.html
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MrMistery
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Post by MrMistery » Mon Dec 12, 2005 6:53 pm

Don't knwo about alcohol's effect on heart cells, but i do know that caffeine activated something called the Rynoadin receptor, a protein located in the endoplasmic reticulum. This is actually a calcium channel that transports it via facilitated diffusion into the cytoplasm. Another level where caffeine function is that it inhibits the production of an enzyme named phosphodiesterase that results in cAMP not being recycled.
About alcohol, all i know about influences on the cardiovascular system is that it determines a peripherical vasodilatation
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countyclare
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Post by countyclare » Mon Dec 12, 2005 11:50 pm

Thanks! :)
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sdekivit
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Post by sdekivit » Tue Dec 13, 2005 8:21 pm

MrMistery wrote:Don't knwo about alcohol's effect on heart cells, but i do know that caffeine activated something called the Rynoadin receptor, a protein located in the endoplasmic reticulum. This is actually a calcium channel that transports it via facilitated diffusion into the cytoplasm. Another level where caffeine function is that it inhibits the production of an enzyme named phosphodiesterase that results in cAMP not being recycled.
About alcohol, all i know about influences on the cardiovascular system is that it determines a peripherical vasodilatation


those receptors are called ryanodine receptors and are involved in the so called calcium-induced calcium-release.

cAMP is also very important in the cardiac contraction, since cAMP binds to the If-channels in the sinoatrial node holding them open for a longer period and thus an increased heart rate.
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MrMistery
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Post by MrMistery » Wed Dec 14, 2005 8:04 pm

spelling is my problem, as always. Oh yeah i forgot to write why cAMP is important. Luckly sdekivit is on guard.
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