DNA repair mechanisms and cancer

Genetics as it applies to evolution, molecular biology, and medical aspects.

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Location: Federal University of Viçosa, Viçosa-MG, Brazil.

DNA repair mechanisms and cancer

Post by Hermanfialho » Sun Jun 23, 2013 11:13 pm

Hi fellows, I have the following question. Sorry by my terrible english...
Suppose that a cell have a established mutation, for example an APC mutation, in each turn of division this mutation can be detected by the mechanisms of DNA repair? If yes, then I believe that cancer would be much improbable... But if not, why the repair mechanisms do not can detect more this mutation if they are functionals...

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Inland Taipan
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Post by JackBean » Wed Jun 26, 2013 2:48 pm

the problem is, that the repair mechanisms can detect only the problem - missing nucleotide in the strain, break in the strain (single stranded or double stranded), mismatch etc. and this leads to some sort of repair (depending on the particular problem). But once it is repaired (even if wrong), the cell has no way to see it's wrong. That's why we are here, otherwise there would be no evolution ;)

Cis or trans? That's what matters.

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