DNA Question
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DNA Question
If an incorrect nucleotide is incorporated into a forming strand of DNA, will this mistake be transmitted to the next generation of DNA molecules that forms from this strand?
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Normally the excision process of the DNA checking mechanism should be able to cut and normalize the DNA. However in rare cases the excision mechanism may not work because of the close structure.
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there are 2 exonuclease activities which is 3'->5' and 5'->3'.
3'->5' = cuts the incorrect base before getting integrated along with the DNA backbone.
5'->3' = cuts the incorrect base after getting integrated along with the DNA backbone. example, the base changing activities by polymerase I in DNA lagging strand after attached one fragment to another by ligase enzyme.
3'->5' = cuts the incorrect base before getting integrated along with the DNA backbone.
5'->3' = cuts the incorrect base after getting integrated along with the DNA backbone. example, the base changing activities by polymerase I in DNA lagging strand after attached one fragment to another by ligase enzyme.
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