BCl-2 Modelling and Kinetic Data

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BCl-2 Modelling and Kinetic Data

Post by ryno » Thu Nov 22, 2012 6:43 pm

Hi all,

I'm very new to the field of biology, and have just recently started researching topics related to Apoptosis.

In order to start building my knowledge base in the field, I thought I'd try to build a simple systems biology model for the BCl-2 family. I tried searching for information I can compile into a signal propagation simulation, but could not quite advance yet.
Although there are numerous databases available online, I found it very hard to draw a basic network of the protein-protein interactions (How can I know I have the complete network?). Moreover, I found it impossible to retrieve any concrete data regarding the kinetics of the problem (time scales, stoichiometry relations, Michaelis-Menten constants etc.).

Does anyone have an idea where to look for such information?
Are there any databases containing such work available?
Existing BCl-2 models (in Celldesigner or other software)?

Thanks in advance,

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