Kinases

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x555
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Kinases

Post by x555 » Sat Sep 22, 2012 9:57 am

I'm thinking about this question regarding kinases and I'm not sure if I have the right answer. What do kinases use as an energy source? Is the answer ATP?

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jonmoulton
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Re: Kinases

Post by jonmoulton » Mon Sep 24, 2012 3:13 pm

You can think of an ATP as an ADP and a phosphate bound together. It is the bond between the ADP moiety and the phosphate moiety that is the highest-energy bond in the molecule. If the terminal phosphate of ATP is transferred to a protein (releasing free ADP) then the system is in a lower-energy state that was the initial ATP and un-phosphorylated protein. That release of energy helps drive the reaction to the ADP & phosphoprotein side.

Not every kinase will use ATP as a substrate. Other high-energy phosphates are available in cells and there are many kinases.

http://en.wikipedia.org/wiki/Kinase

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Post by x555 » Tue Sep 25, 2012 9:18 am

Thank you very much!

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