Enzymes

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderators: Leonid, amiradm, BioTeam

rk386
Garter
Garter
Posts: 26
Joined: Mon Aug 06, 2012 3:20 pm

Enzymes

Post by rk386 » Mon Aug 06, 2012 3:36 pm

Do enzymes in the body last permanently, or do they over time get broken down and then replenished/rebuilt/replaced? Also, what controls the amount of enzyme present?

User avatar
jonmoulton
Viper
Viper
Posts: 442
Joined: Fri Feb 15, 2008 5:38 pm
Location: Philomath, Oregon, USA

Re: Enzymes

Post by jonmoulton » Tue Aug 07, 2012 3:32 pm

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

This page might help the system make more sense.

http://en.wikipedia.org/wiki/Proteolysis

david23
Coral
Coral
Posts: 430
Joined: Thu May 03, 2007 8:15 am

Re: Enzymes

Post by david23 » Tue Aug 07, 2012 10:08 pm

what controls the enzyme levels? your genes, and hormonal regulations which again your genes

User avatar
JackBean
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Post by JackBean » Tue Aug 07, 2012 10:16 pm

you seem to put everything under genes, but genes are controlled by many factors as well
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

rk386
Garter
Garter
Posts: 26
Joined: Mon Aug 06, 2012 3:20 pm

Re: Enzymes

Post by rk386 » Wed Aug 08, 2012 6:17 pm

Thanks. Follow-up question:

Enzymes are degraded over time. Some are relatively short-lived while others are very persistent, but damage accumulates and they are eventually broken down.

Is it known which types of enzymes break down quickly and which are persistent?

User avatar
JackBean
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Post by JackBean » Wed Aug 08, 2012 6:33 pm

Yes, there are soe well-known examples. For those you don't know about, you can make some predictions.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

rk386
Garter
Garter
Posts: 26
Joined: Mon Aug 06, 2012 3:20 pm

Re: Enzymes

Post by rk386 » Wed Aug 08, 2012 9:47 pm

Thanks. If I wanted to look more into this, where would I look?

User avatar
JackBean
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Post by JackBean » Wed Aug 08, 2012 10:03 pm

The first choice should be Alberts' The Cell
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

rk386
Garter
Garter
Posts: 26
Joined: Mon Aug 06, 2012 3:20 pm

Post by rk386 » Wed Aug 08, 2012 10:07 pm

Oh, great, I have that.

User avatar
jonmoulton
Viper
Viper
Posts: 442
Joined: Fri Feb 15, 2008 5:38 pm
Location: Philomath, Oregon, USA

Re: Enzymes

Post by jonmoulton » Thu Aug 09, 2012 3:19 pm

Look for "protein turnover". Here's an introduction. http://en.wikipedia.org/wiki/Protein_turnover

rk386
Garter
Garter
Posts: 26
Joined: Mon Aug 06, 2012 3:20 pm

Post by rk386 » Wed Aug 15, 2012 4:04 pm

Thanks. Have studies on protein turnover been done for specific proteins, or is it just known in general that that is what happens?

User avatar
jonmoulton
Viper
Viper
Posts: 442
Joined: Fri Feb 15, 2008 5:38 pm
Location: Philomath, Oregon, USA

Post by jonmoulton » Wed Aug 15, 2012 4:50 pm

It has been done for many specific proteins. One good method is pulse-chase analysis. http://en.wikipedia.org/wiki/Pulse-chase_analysis

Post Reply

Who is online

Users browsing this forum: No registered users and 1 guest