hexokinase conformation

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andrewJM
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hexokinase conformation

Post by andrewJM » Sat Jul 21, 2012 4:45 pm

Hi,
I've been researching the phosphorylation of glucose, catalysed by hexokinase - reaction 1 of glycolysis. I've found plenty of pdb structures in the protein data bank, but not found any showing the enzyme conformation with glucose binding.
"Fundamentals of Biochemistry" by Donald and Judith Voet, has nice diagrams in fig. 14-2, and the book's CDROM gives the pdb structures 2YHX and 1GLK, but these don't seem to match the diagrams.
I'd like to find pdb structures to illustrate how hexokinase conforms to bind ATP and glucose, with the ligands enclosed inside the molecule. I'd be grateful for any help.

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