Cis-Platin and Its Effects on DNA Replication

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Positron
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Cis-Platin and Its Effects on DNA Replication

Post by Positron » Tue Apr 24, 2012 4:14 pm

Before I ask my question, I would like to state that I am not a Biology student. I am actually a Chemistry student who has a small section on Biochemistry in his syllabus.

Now, my problem lies with part (ii).

Mechloroethamine obviously hold the DNA strands together and prevents the DNA helix from uncurling/unzipping. Hence, the very first stage in replication is impeded.

How cis-platin affects DNA replication is eluding me. I know that Guanine normally forms 3 hydrogen bonds with Cytosine. However, it seems to be forming only one hydrogen bond in this case.

Could someone prod me in the correct direction ?
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Post by Positron » Wed Apr 25, 2012 5:24 pm

bump

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JackBean
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Post by JackBean » Wed Apr 25, 2012 5:43 pm

http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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Post by Positron » Sat Apr 28, 2012 8:50 am

That doesn't really answer the question above.

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canalon
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Post by canalon » Sat Apr 28, 2012 2:23 pm

From http://en.wikipedia.org/wiki/Cisplatin
1- the dashed line appear to be no more than just a representation of the 3 H bond between G and C not an accurate representation.
2- Cis-platin do intra strand and interstrand crosslinking. Both interfere with replication (I suspect intrastrand crosslinking might even change the correct DNA structure) sterically and by prevent correct unzipping of the DNA double helix
Patrick

Science has proof without any certainty. Creationists have certainty without
any proof. (Ashley Montague)

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