Cell proliferation limit and senescence (ES and fibroblasts)

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alexia29
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Cell proliferation limit and senescence (ES and fibroblasts)

Post by alexia29 » Sat Mar 31, 2012 5:44 pm

Hello,
I am trying to understand the importance of proliferation limits and cell senescence. In particular, one of my homework questions is asking to compare the proliferation limit of Embryonic Stem cells (ES) and fibroblasts (which would be trans-differentiated) and describe how this difference plays a role when thinking about engineering organs, for example a heart transplant.

Any help? How do ES cells and fibroblasts compare with regards to the Hayflick limit?
_______________________________________________________________________
Here is what I am thinking, however I am not sure if this is correct or not.
Non-differentiated the ES cells can divide almost indefinitely, however when the stem cell differentiates into a specific function, it goes through approximately 50 cell divisions before senescence. On the other hand, fibroblasts have already gone through some cell divisions at the point when they are trans-differentiated. Therefore, their life before senescence is less than 50 cell divisions.

Can someone verify this?
Thank you.

kaushalmku
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Re: Cell proliferation limit and senescence (ES and fibroblasts)

Post by kaushalmku » Sun Apr 22, 2012 7:31 pm

alexia29 wrote:Hello,
I am trying to understand the importance of proliferation limits and cell senescence. In particular, one of my homework questions is asking to compare the proliferation limit of Embryonic Stem cells (ES) and fibroblasts (which would be trans-differentiated) and describe how this difference plays a role when thinking about engineering organs, for example a heart transplant.

Any help? How do ES cells and fibroblasts compare with regards to the Hayflick limit?
_______________________________________________________________________
Here is what I am thinking, however I am not sure if this is correct or not.
Non-differentiated the ES cells can divide almost indefinitely, however when the stem cell differentiates into a specific function, it goes through approximately 50 cell divisions before senescence. On the other hand, fibroblasts have already gone through some cell divisions at the point when they are trans-differentiated. Therefore, their life before senescence is less than 50 cell divisions.

Can someone verify this?
Thank you.

can i do this assignment?

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JackBean
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Post by JackBean » Mon Apr 23, 2012 12:41 pm

That seems all right to me.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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