FADPH

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yurixsa
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FADPH

Post by yurixsa » Sat Sep 17, 2005 11:33 pm

Hi, I was wondering if someone could help me with this, I was reviewing through oxidation of polyunsaturated fatty acids Example: Linoleic Acid (18:2), in one reduction step you use NADPH to oxidize a double bond. My question is what amount of ATP value does NADPH have, is it 1 ATP, 2 ATP, I've haven't been able to figure it out. Can anyone help?

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canalon
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Post by canalon » Sun Sep 18, 2005 12:06 am

We had this discussion not long ago here:http://www.biology-online.org/biology-forum/viewtopic.php?t=2301&highlight=nadph And a few more times. We have a search engine do not hesitate to use it, you won't break it, believe me :wink:

Patrick

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thank you but it didn't help

Post by yurixsa » Sun Sep 18, 2005 12:21 am

Hi, Thanks for responding so promptly, I had actually done that, but I didn't find the answer I was looking for. I understand that FADH2 results in 1.5 ATP molecules per electron pair and NADH results in formation of about 2.5 molecules of ATP, what I want to know is how much ATP is used when you use NADPH in a reduction step (for example in the oxidation of linoleic acid which as 18 carbons and 2 double bonds. Also on another note, for every acetyl-CoA produced you get 10 ATP, do you know if you get any ATP for the production of Succinyl-CoA, it is one of the end products of oxidation of an odd-number fatty acid (for example: propionate, 3 carbons, no double bonds). Thanks for your time.

Canalon wrote:We had this discussion not long ago here:http://www.biology-online.org/biology-forum/viewtopic.php?t=2301&highlight=nadph And a few more times. We have a search engine do not hesitate to use it, you won't break it, believe me :wink:

Patrick

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canalon
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Re: thank you but it didn't help

Post by canalon » Sun Sep 18, 2005 2:39 am

yurixsa wrote: what I want to know is how much ATP is used when you use NADPH in a reduction step (for example in the oxidation of linoleic acid which as 18 carbons and 2 double bonds. Also on another note, for every acetyl-CoA produced you get 10 ATP, do you know if you get any ATP for the production of Succinyl-CoA, it is one of the end products of oxidation of an odd-number fatty acid (for example: propionate, 3 carbons, no double bonds). Thanks for your time.


For the first question, As far as I understand, the answer is none. You do not need ATP, there is enough NADPH in the cell to do the job without creating some for this occasion. It's just that some of the NADPH will not yield any ATP.

As for the second, you will find the answer if you go down to entry 17.1.7 of this page.

Hope You got your answers

Patrick

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