Membrane Protein

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biomeeh
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Membrane Protein

Post by biomeeh » Mon Dec 05, 2011 5:15 am

I need some help with my assignment in cell biology. I can't find this topic on my book. And I'm confused if this 2 and 3 dimensional representation is the same with the 2 and 3 dimensional structure of proteins.

Here are the questions:

1. What is the difference between a two dimensional and a three dimensional representation of membrane protein?

2. How are the different profile obtained, and which is more useful?

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JackBean
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Re: Membrane Protein

Post by JackBean » Mon Dec 05, 2011 7:59 am

by 2D representation of TM protein you mean something like this?
Image
If so, the difference is that in 2D you show secondary structure, while in 3D, it's surprisingly tertiary structure
Image

Depends for what more useful, for mode-of-action is more useful the 3D, for showing, where did you introduce some mutations, the 2D picture may be better (unless you have more mutations, far apart from each other on the peptide and you want to show, that they are close to each other in 3D).
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

biomeeh
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Re: Membrane Protein

Post by biomeeh » Mon Dec 05, 2011 9:15 am

JackBean wrote:by 2D representation of TM protein you mean something like this?
http://blog.pansapiens.com/wp-content/u ... _bucai.png
If so, the difference is that in 2D you show secondary structure, while in 3D, it's surprisingly tertiary structure
http://blog.pansapiens.com/wp-content/u ... mb_ray.jpg

Depends for what more useful, for mode-of-action is more useful the 3D, for showing, where did you introduce some mutations, the 2D picture may be better (unless you have more mutations, far apart from each other on the peptide and you want to show, that they are close to each other in 3D).


Thank you so much! If you don't mind, can you explain it further for me or if you have some links to websites where I can find more elaborate explanations so that I could understand it better.

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JackBean
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Post by JackBean » Mon Dec 05, 2011 10:30 am

what do you need more explain?
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

biomeeh
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Post by biomeeh » Mon Dec 05, 2011 11:09 am

Yes. I really need to understand this topic and I can't find any article or explanation from our book.

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jonmoulton
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Re: Membrane Protein

Post by jonmoulton » Mon Dec 05, 2011 5:51 pm

Focus on the key terms that Jack used: secondary structure, tertiary structure. Take a look at this Wikipedia page:
http://en.wikipedia.org/wiki/Biomolecular_structure

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