Ouabain and Na/K ATPase inhibition

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Ouabain and Na/K ATPase inhibition

Post by nikkilici0us » Wed Oct 19, 2011 7:23 pm

I have this question to answer for my cell bio class:

"During the transport process, the Na/K ATPase becomes transiently phosphorylated. What do you think this suggests about a likely mechanism for ouabain inhibition of this pump? How might this reaction be reversed, both endogenously and experimentally?"

So.. we know that ouabain inhibits the binding of phosphate.. by inhibiting a kinase.
But how would this be reversed endogenously and experimentally?


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Inland Taipan
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Post by JackBean » Thu Oct 20, 2011 7:28 am

that depends on the mechanism of ouabain

Cis or trans? That's what matters.

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