Ouabain and Na/K ATPase inhibition

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
nikkilici0us
Garter
Garter
Posts: 2
Joined: Wed Oct 19, 2011 7:19 pm

Ouabain and Na/K ATPase inhibition

Post by nikkilici0us » Wed Oct 19, 2011 7:23 pm

I have this question to answer for my cell bio class:

"During the transport process, the Na/K ATPase becomes transiently phosphorylated. What do you think this suggests about a likely mechanism for ouabain inhibition of this pump? How might this reaction be reversed, both endogenously and experimentally?"

So.. we know that ouabain inhibits the binding of phosphate.. by inhibiting a kinase.
But how would this be reversed endogenously and experimentally?

Thanks!
Nikki

User avatar
JackBean
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Post by JackBean » Thu Oct 20, 2011 7:28 am

that depends on the mechanism of ouabain
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

Post Reply

Who is online

Users browsing this forum: Google Adsense [Bot] and 10 guests