Primary protein structure and the roles of proteins

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
User avatar
punk rock princess
Garter
Garter
Posts: 16
Joined: Fri Sep 02, 2005 2:02 pm

Primary protein structure and the roles of proteins

Post by punk rock princess » Fri Sep 09, 2005 3:15 pm

Hi guys! :P

I was wondering - in what ways does the primary structure of proteins affect the various roles/functions of the protein?

Can anyone help?

User avatar
canalon
Inland Taipan
Inland Taipan
Posts: 3909
Joined: Thu Feb 03, 2005 2:46 pm
Location: Canada

Post by canalon » Fri Sep 09, 2005 3:26 pm

Different level of protein structure:
Primary: Amino Acid sequence
Secondary: formation of Alpha helices and Beta sheets
Tertiary: Complete folding of the protein
Quaternary: (if needed) association of different polypeptides

So your questions is how change is the sequence affects the other levels and and fuction of your enzyme. It shouldn't be too hard to finish your homeworks now, should it?

Patrick

User avatar
victor
King Cobra
King Cobra
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..
Contact:

Post by victor » Sat Sep 10, 2005 11:07 am

change in primary stucture (amino-acids) sequence....I guess it affects the work of the protein significantly..
Q: Why are chemists great for solving problems?
A: They have all the solutions.

baikuza
Coral
Coral
Posts: 429
Joined: Tue Aug 30, 2005 10:09 am
Location: Yogyakarta, indonesia, south-east asia
Contact:

Post by baikuza » Tue Sep 13, 2005 10:24 am

8) mm....
victor is right..

when there are some of amino acid that form the protein... just take lisozim as the example. then if the formation of amino acid has changed so.. are u call it by lisozim? actually if the formation changed automaticly the works of protein become differ to the first function....

the function of proteins depend on its primary structure of proteins.

I hope it's clear enough. :wink:

User avatar
punk rock princess
Garter
Garter
Posts: 16
Joined: Fri Sep 02, 2005 2:02 pm

Post by punk rock princess » Tue Sep 13, 2005 11:28 am

Thanks :)

User avatar
victor
King Cobra
King Cobra
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..
Contact:

Post by victor » Tue Sep 13, 2005 11:37 am

Hmm...that reminds me about this:
all the proteins that we ate are poison..example like this, there's one protein structure that we eat like this: N-I-A-K (this is one symbolic amino acid). But our body will cut this protein ans let our blood system carry them in amino-acud fragment (since this is poisonous, this protein must be 'cut' quickly). After that our body will form a new type of protein according to their need. They can form: K-A-I-N, N-A-I-K, K-I-N-A, etc. that are useful for our body.
This explains that the sposition of amino-acids and the stucture of the protein really determine these words: "poison" or "nutrition".
Q: Why are chemists great for solving problems?
A: They have all the solutions.

User avatar
canalon
Inland Taipan
Inland Taipan
Posts: 3909
Joined: Thu Feb 03, 2005 2:46 pm
Location: Canada

Post by canalon » Tue Sep 13, 2005 2:39 pm

baikuza wrote:8) mm....
victor is right..

when there are some of amino acid that form the protein... just take lisozim as the example. then if the formation of amino acid has changed so.. are u call it by lisozim? actually if the formation changed automaticly the works of protein become differ to the first function....

the function of proteins depend on its primary structure of proteins.

I hope it's clear enough. :wink:


True, but achange in primary sequence maybe neutral too. Depends on the nature and location where it happens. If most of the change in the active site of the protein make it probably defective, some other aa just serve as "spacers" for the active site to be at the right place (I am oversimplifying here..) or to provide the right caracter to one place of the protein (hydro-phobic/philic) and can be modified provided the new aa is not causing a drastic change in those functions...

Patrick

User avatar
victor
King Cobra
King Cobra
Posts: 2668
Joined: Sat Apr 30, 2005 12:01 pm
Location: Yogyakarta, Indonesia..
Contact:

Post by victor » Wed Sep 14, 2005 11:12 am

so, the key is only on the active side.. :lol:
Q: Why are chemists great for solving problems?
A: They have all the solutions.

User avatar
canalon
Inland Taipan
Inland Taipan
Posts: 3909
Joined: Thu Feb 03, 2005 2:46 pm
Location: Canada

Post by canalon » Wed Sep 14, 2005 1:13 pm

victor wrote:so, the key is only on the active side.. :lol:


Nope,
as always there are 2 sides to the mutation question :wink: :
- Catalytic activity, or the active site
- Structural integrity, both in terms of conformation and exposed surface

Patrick

Post Reply

Who is online

Users browsing this forum: No registered users and 2 guests