Do B cells have receptors and antibodies

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Do B cells have receptors and antibodies

Post by snezka18 » Tue May 10, 2011 8:26 am


Do B cells have B cell receptors, antigen receptors and also antibodies, or they basically have receptors and basically plasma b cells carry antibodies, they secrete antibodies
So do naive, not yet activated (but immunocompetent) have its own antigenic receptors, but how do they know how to respond to foreign antigens (bc they mature in the bone marrow and they know which ones are self antigens), but how would they bind to a foreign antigen if they dont know if it will fit? Isnt it like a lock key mechanism? how do they know what kind of shape of receptors do have, it that the role of antibodies then?

Hope someone can help me!!

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Post by Babybel56 » Tue May 10, 2011 6:51 pm

Mature naive B-cells have undergone VDJ recombination to give each of them a unique antigen presented on its surface, but they don't start secreting antibodies until they're activated by a foreign antigen. So the plasma cells don't become plasma cells until they've encountered a foreign antibody that's presented by a CD4 T-cell or similar.
Whether a B-cell becomes a plasma cell is basically a matter of chance. A complete inventory of antigens are created (one type per B-cell, with those that are self-reactive or non-productive removed) and those that happen to recognise the foreign antibody will proliferate and differentiate into the plasma cells. Those that don't will just circulate within the lymph system until their lifespan's up!

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