Question about CJD

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Brodo
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Question about CJD

Post by Brodo » Thu Mar 31, 2011 5:24 am

I would just like to confirm my understanding of CJD (creutzfeldt Jakob Disease)

My notes say that the PrPc protein is converted by some unknown protein x into PrP*
Would this protein x be the prion?

Also, the effect of this conversion is that the PrP* will use a PrPsc protein as a template to convert PrP* into another PrPsc. Where did this initial PrPsc protein come from?

Thank you

Darby
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Post by Darby » Thu Mar 31, 2011 3:21 pm

The assumption is that the protein is maybe from a mutated code, with a change that a) makes it fold up differently, and b) produces a form that can reconform the "regular" version into something like it.

Brodo
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Re: Question about CJD

Post by Brodo » Thu Mar 31, 2011 11:10 pm

Okay, thanks.
But is protein x a prion?

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canalon
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Post by canalon » Fri Apr 01, 2011 3:06 am

generally yes.
Patrick

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