cellular addressing question

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cellular addressing question

Post by JS » Sun Aug 14, 2005 1:19 am

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Jelanen
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Post by Jelanen » Sun Aug 14, 2005 1:27 am

I'm not sure where you would find this information (my texts are still packed, yeah, I'm lazy) but the entire cell has three dimensional physical addresses laid out and demarcated with the cytoskeleton. I'm not up on the current research in the field (bad Jelanen), but that was what I had heard. I'm sure by now they've clarified some of these issues on how.
-Jelanen

Oh, and please read the forum rules before posting questions...
'It is futile to pretend to the public that we understand how an amoeba evolved into a man, when we cannot tell our students how a human egg produces a skin cell or a brain cell!'

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Post by JS » Sun Aug 14, 2005 1:55 am

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Post by Dr.Stein » Sun Aug 14, 2005 8:59 am

I have no idea about the question, but there are some things in my head during reading the statement. Perhaps one of them might be your idea... It could be:
- signaling transduction pathway
- protein transmembrane receptor
- exocytosis with clathrin
- ...

:(
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Post by JS » Sun Aug 14, 2005 10:07 am

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Post by Dr.Stein » Sun Aug 14, 2005 11:26 am

Yes, you should explain us for better what you were talking about with those guys, I think... :)
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Post by JS » Sun Aug 14, 2005 9:35 pm

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Post by Dr.Stein » Mon Aug 15, 2005 2:24 am

Wow, this is new for me :) Now I can see the idea. It is about synthesizing novel protein to change the 'behavior' of the cell, isn't it? In normal condition, protein or glycoprotein package will be surely sent out of the cell via secretory granules under the stimulation of extracellular order (for instance, hormone). Intracellular order will initiate protein synthesis that will be used internally by the cell, packed in microbodies, means that this kind of protein will not be externalized. Hmm... I think this is the problem here...

Could you tell me the structure of slime mold membrane substance that can do that connection? I believe it is not just a simple lipoprotein, there must be a special carbohydrate structure over there, possibly a lectin...? It is the most primitive structure to function in adhesion purpose (cognate interaction). We should get this point first.. If it is a lectin we can go on. If it is not, then we should dig to get something else. Whoaa, this makes my gears spin and spin :)
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Post by JS » Mon Aug 15, 2005 4:53 am

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Post by Dr.Stein » Mon Aug 15, 2005 10:19 am

I got the answer : acrasin, now known to be cAMP, is a pheromone that is responsible for aggregation in slime mold Dictyostelium discoideum :wink:

Read HEREfor a complete understanding

Whoaa, my "prognosis" is correct, it is all about signaling transduction pathway and protein transmembrane receptor yeah! 8) :D

My double-thumb-up for our sweet Emily Fertig :)
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Post by JS » Mon Aug 15, 2005 10:54 am

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Post by Dr.Stein » Mon Aug 15, 2005 2:23 pm

Aah, this problem seems never end eh? :?

Well, now you understand the basic structure and mechanism on how slime molds aggregate. Sorry, but I must say, in my opinion, that what you think is a big maneuver, that you leap too fast from our knowledge. I think I understand the meaning of what people said to you according to your idea :wink:

If you really want to observe this, not just thinking any possibilities, sorry, you need to do such experiment on simpler individual, which has just few levels further from where slime molds are in the systematics. Watching for the result, if you get something good then just do it step by step until you get the answer of your question. If you found nothing then just change your hypothesis. It seems like thousands miles for you to get it finally...but it could be just at a glance if you found the key. Good luck! :)
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