GDP_pKa_Query

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
CoffeeIsTheColour
Garter
Garter
Posts: 5
Joined: Fri May 14, 2010 11:59 am

GDP_pKa_Query

Post by CoffeeIsTheColour » Thu Nov 04, 2010 11:10 am

Hi all,

Generally, I was wondering what the pka of GDP is? In particular, I'm interested in the state of it in the cell, i.e pH ~7.4.

I found this...pKa - <1
2.9
6.3
9.6

I would assume that these are the corresponding pKa's while progressively deprotonating the molecule, so <1 corresponds to all 3 OH groups being protonated and 9.6 corresponds to all 3 OH groups deprotonated.

Is this about right?

If so, then it would make sense that at pH 7.4 there would be one OH phosphate group protonated. Is this right? Then if so, which one, alpha or beta phosphate?

Many thanx,

M

User avatar
JackBean
Inland Taipan
Inland Taipan
Posts: 5694
Joined: Mon Sep 14, 2009 7:12 pm

Post by JackBean » Wed Nov 24, 2010 10:17 am

I guess it is better to have one charge on two groups rather then two charges on one group and the other uncharged...
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

Post Reply

Who is online

Users browsing this forum: No registered users and 2 guests