Chromosome translocations?

Genetics as it applies to evolution, molecular biology, and medical aspects.

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sam2400
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Chromosome translocations?

Post by sam2400 » Sat May 08, 2010 10:36 am

Does anyone know how a reciprocal translocation can cause chromosome imbalance during meiosis?

sorin
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Post by sorin » Thu May 13, 2010 1:39 pm

it depends on the segregation of the homologous chromosomes whether the reciprocal translocation is balanced or imbalanced. Genetic material my become exchanged (or is already exchanged, if the individual is a carrier of a balanced translocation) in the germline (e. g. translocation between chr 9 and 22 --> cell with each one chrom 9 and 22, and two chrom t(9;22)). If during anaphase 1 one normal and one abnormal chromosome is transferred to a cell this results in a loss/excess of certain genes. This would not be the case if the two normal chrom 9 and 22 or the two abnormal t(9;22) chromosomes are separated together.

akki313
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Post by akki313 » Sun May 16, 2010 5:47 pm

After the process of reciprocal translocation between two non homologous chromosomes.. There occur the formation of a cross like structure between those chromosomes because arms of one chromosome is similar to that of two different chromosomes. This cross like structure involves four chromosomes i.e 2 normal chromosomes and 2 mutated chromosomes.

After the formation of cross like structure there occur segregation in 3 ways:
1. Alternate Segregation
2. Adjecent 1 segregation
2. Adjecent 2 segregation

You can refer following image for the whole process.
http://sapientfridge.org/chromosome_cou ... 201-6.jpeg

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