the n and c terminus

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llyneth28
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the n and c terminus

Post by llyneth28 » Tue Apr 27, 2010 12:48 pm

Why are the amino acids near the n and c terminus of proteins difficult to resolve by x-ray crystallography.

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JackBean
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Post by JackBean » Tue Apr 27, 2010 1:47 pm

because the ends are usually at the surface of the protein and are flexible and thus "invisible" for X-ray. It's similar like whit some loops, which are disordered until the substrate is bound ;)
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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