Effect of protein denaturing on a) cell b) organism

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Effect of protein denaturing on a) cell b) organism

Post by TomTomTom » Mon Apr 26, 2010 6:57 am

Hi iv been doing a bit of reading on the effect of pH changes on cell. So far i'v found that the changes in structure due to the loss and gain of Hydrogen ions in chains of amino acids forming proteins causes the protein to change shape (denaturing)

My question is what happens to a) the cell and its contents when the protein is dennatured. My guess is that the effect is just cell death as it cannot function without protein(??)..do the contents of the cell diffuse out etc?
If so what would likely happen to the organism? death?

p.s sorry if this is a double post not sure if the first one went through.

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Post by JackBean » Mon Apr 26, 2010 11:03 am

I think there's no way to have such extreme pH in the cell to denature proteins (maybe rupture of lysosome, but it would be diluted again...)
But yes, proteins would be denatured, membranes broken and the cell would lyse.
If this happened in one cell of multicellular organism, nothing would happen, they lysed parts would be taken up by white blood cells (if talking about such multicellular organisms) or degraded in other way.
If that happened in more cells, than whole tissue could be destroyed

Cis or trans? That's what matters.

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