plasma membrane & protein orientation

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klapausius
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plasma membrane & protein orientation

Post by klapausius » Sun Apr 18, 2010 1:40 pm

which of the following statements is true about the orientation of the proteins in the plasma membrane?

(a) the orientation is changed by increasing fluidity of lipids in the bilayer
(b) the orientation is changed by using enzymes that rotate proteins through the lipid bilayer
(c) the orientation is changed by budding and fusing of membrane vesicles
(d) the orientation of membrane proteins cannot be changed

My guess (b)
my thoughts;
(a) increasing fluidity will only affect its location at the non-cystolic leaflet
(c) budding and fusing wont change the orientation, usually be maintained
(d) then we dun need flippase

im not sure whether b) is correct though

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JackBean
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Post by JackBean » Sun Apr 18, 2010 2:05 pm

flippase is for lipids, not for proteins, IMHO d is correct
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

klapausius
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Post by klapausius » Sun Apr 18, 2010 5:12 pm

thanx appreaciate it!

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MrMistery
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Post by MrMistery » Mon Apr 19, 2010 12:42 am

jackbean is right. the orientation of a protein is established when it is inserted into the membrane of the ER, and can never be changed
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

lehua768
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Post by lehua768 » Thu Apr 22, 2010 5:31 am

jackbean is right. the orientation of a protein is established when it is inserted into the membrane of the ER, and can never be changed
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter
Last edited by JackBean on Thu Apr 22, 2010 8:02 am, edited 1 time in total.
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