what does "turnover" mean in cell biology?

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raji
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what does "turnover" mean in cell biology?

Post by raji » Sun Mar 28, 2010 5:27 am

for a protein in a cell, what does "turnover" mean? for example, when you say "turnover of protein A is larger than that of protein B", what does this mean? dose it have anything with biochemistry as well?
thanks

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jwalin
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Post by jwalin » Sun Mar 28, 2010 7:43 am

most probably it means that the total output of protien A is larger than the toatl output of protien B
99% this is right
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JackBean
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Post by JackBean » Sun Mar 28, 2010 8:43 am

output? And what is output?
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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jwalin
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Post by jwalin » Sun Mar 28, 2010 3:02 pm

output as in production... as in the amount that is produced
it isn't what you do that matters but it is how you do it

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JackBean
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Post by JackBean » Sun Mar 28, 2010 4:26 pm

than you're wrong :-P

turnover means the net of synthesis and degradation, defining the half-life of protein.
Higher turnover probably means, that the protein is synthesised and degraded faster
http://sandwalk.blogspot.com/2007/06/pr ... nover.html
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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jwalin
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Post by jwalin » Mon Mar 29, 2010 11:10 am

ohk...
mmm... :S
the word net suggests...
amount produced - amount degraded

while the third line suggests
amount produced + amount degraded

sorry but i got a little confused...
which one is the right one :?:
it isn't what you do that matters but it is how you do it

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mith
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Post by mith » Tue Mar 30, 2010 12:02 am

It's not describing the total amounts, it's describing the rates of production and degradation.
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Post by david23 » Tue Mar 30, 2010 9:35 pm

Yeah turn over, half lives, it's just a description of how long it will stay around before it can no longer be detected or functional. It's usually measured as a time value but you can make it a rate thing. Like the RBC turns over every 120 days or this drug's half life is 5 hours.

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