Pedigree

Genetics as it applies to evolution, molecular biology, and medical aspects.

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kasiaogor
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Pedigree

Post by kasiaogor » Fri Feb 12, 2010 7:15 pm

I have a problem which corresponds to the pedigree analysis. There is a disease which is inherited by X-linked recessive. The problem is that the father is affected (XaY) and the mother is homozygote (XAXA). They have 4 children, 2 sons and 2 daughters. The sons are not affected (XAY) and one of the daughter is affected (XaXA). The other daughter is not affected. The problem is that she should be affected but she isn´t. What could be the possible cause of that??

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JackBean
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Post by JackBean » Fri Feb 12, 2010 7:40 pm

IMHO both daughters will be carriers, but any will be affected (it's recessive)
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

kasiaogor
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Post by kasiaogor » Fri Feb 12, 2010 7:43 pm

I know that both of them should be carriers but one of them isn´t. The problem is to find why. What can cause that.

Haidarh
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Post by Haidarh » Fri Feb 12, 2010 8:52 pm

There may have been a positive mutation in the gene led to the reform of the error in the gene expression resulting in the gene properly second girl

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