repeat sequence in DNA and mispairing

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sarah90222
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repeat sequence in DNA and mispairing

Post by sarah90222 » Wed Jan 06, 2010 3:35 pm

i had this lecture about mutations occuring in dna and one of the sections mentions the problems with repeat sequences and how they can have pathogenic potentials

it says short tandem repeats can mispair and cause pathogenic deletions and insertions which cause a frameshift.

i would be really grateful if someone can explain the above to me. I read online it is more likely at repeats sequences to get slipped strand mispairing. I can see how if this bit is excised can cause a deletion but how the hell can mispairing cause insertions? Or have I understood it wrong?

im really confused

kolean
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Post by kolean » Thu Jan 07, 2010 1:41 am


sarah90222
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Post by sarah90222 » Thu Jan 07, 2010 5:31 pm

thanks :D

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