Which metalloenzyme is most found in mitochondria?

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ATPenergy
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Which metalloenzyme is most found in mitochondria?

Post by ATPenergy » Thu Dec 24, 2009 3:55 am

Which metalloenzyme is most found in mitochondria?
A.Cu metalloenzyme
B.Mg metalloenzyme
C.Mn metalloenzyme
D.Cd metalloenzyme
E.Zn metalloenzyme

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JackBean
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Post by JackBean » Thu Dec 24, 2009 11:43 am

Cd for sure not. Also Zn, Mn and Cu are probably minor, so Mg will be the most found one :wink:
http://www.biolib.cz/en/main/

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MrMistery
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Post by MrMistery » Thu Dec 24, 2009 10:36 pm

It's actually Fe. But also Cu: cytochrome oxidase has a Fe-Cu bimetallic center. I don't know of any mitochondrial enzymes with Mg, Cd or Zn.
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JackBean
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Post by JackBean » Thu Dec 24, 2009 11:20 pm

Mg is in any enzyme binding phosphate in any form. But they are probably not located in mitochondrion...

I was looking to UniProt, and althrought there are not all proteins, iron and cuprum seems to lead :)
http://www.uniprot.org/uniprot/?query=o ... d#9993,479
(for me :( )
http://www.biolib.cz/en/main/

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MrMistery
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Post by MrMistery » Mon Dec 28, 2009 7:51 am

well yeah, DNA polymerases and RNA polymerases have Mg ions, but in the mitochondria the respiratory enzymes outnumber all other proteins by far. So yeah, Fe probably leads as it is found in both those Fe-S centers of Riske proteins but also in the Fe-Cu centers. Cu are only in the Fe-Cu centers. No idea why the person didn't include Fe in the answer choices.
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MrMistery
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Post by MrMistery » Mon Dec 28, 2009 7:53 am

scratch that, the ATP synthase also has Mg. I still think there is more of the Cu ones though. that uniprot link doesn't have Mg unfortunately
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qqsvery
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Post by qqsvery » Tue Dec 29, 2009 6:29 am

you guys were all wrong!Mn diversity cell line panel is the most~the Mn-SOD is the most in mitochondrion!
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