cell cycle control mechanisms

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
sarah90222
Garter
Garter
Posts: 10
Joined: Sun Oct 11, 2009 6:20 pm

cell cycle control mechanisms

Post by sarah90222 » Sun Oct 25, 2009 4:02 pm

i know that the cdks help the cell overcome the different checkpoints. But in different text books and online they refer them as G1/S cdk, and G2/M cdk. Are they the same as S cdk and M cdk? So what's with the G1 and G2 at the beginning?

kolean
Coral
Coral
Posts: 345
Joined: Thu Jun 25, 2009 3:15 am

Post by kolean » Sun Oct 25, 2009 9:35 pm

You have to remember to keep cdks in check with different organism models.

S. pombe has only one mitotic cyclin (Cdc13) and one cdk (Cdc2) that goes thru the whole cell cycle.

S. cerevisiae and Vertebrates have complex cyclins and cdks for each phase of the cell cycle: G1, S, G2, and M phases.

For example, there is Cyclin D with CDK4 and CDK6 in G1 to make sure there is no DNA damage before going on to the S phase. Thus CDK4 and CDK5 are Mid-G1 CDKs, for vertebrates. CDK2 is then used by vertebrates to make sure that all the DNA has been duplicated and contains no errors (before moving into the M phase), and classified as a Late-G1 and also the S phase cdk.

Post Reply

Who is online

Users browsing this forum: No registered users and 5 guests