embryo fusion?

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Dr.Stein
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Post by Dr.Stein » Tue Jul 19, 2005 12:56 am

Actually it would be applied to human as well, to cure autoimmune disease.
Since peripheral lymphocytes from mice A recoqnizise self antigens as nonself ones, they should be eliminated not to destroy body cells any further. That's the irradiation purpose. Beside it will kill all effector cells and antibodies in peripheral circulation, it also will erase the immunological memory, thus in this time mice A is very susceptible. They need to educate naïve lymphocytes those still stay in thymus. By transferring new lymphocytes from another mice, say mice B, they will recoqnize body cells of mice A as self (because they grow in mice A's environment) then they will educate their naïve step sisters (mice A's original lymphocytes) so now they recoqnize their own cells as self and no autoimmune disease anymore.
It's somewhat complicated, hopefully my explanation will not make it to be more complicated :D
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Post by protozoan » Tue Jul 19, 2005 9:36 am

How do lymphocytes from mice B educate native lymphocytes in mice A to not to recognize self body cells as nonself? I could understand that lymphocytes from mice B brings new imuno memory to the body of mice A, but native lymphocytes of mice A in the thymus should stay same.
When you have eliminated all which is impossible, then whatever remains, however improbable, must be the truth. (Sherlock Holmes)

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Post by Dr.Stein » Tue Jul 26, 2005 11:22 am

Well, it is not the idea...
The cells coming from mouse B are naïve, as naïve as the remain cells in thymus of mouse A. Because those cells are grown in mouse A, in the periphery they will recognize mouse A's cells as self.

About naïve lymphocytes in thymus, they will undergo antigen-independent and antigen-dependent maturation. In this period, the self and nonself recognition is very important. Who will tell them which one is self and nonself? Of course, the peripheral environment. That's it.
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Post by protozoan » Sun Jul 31, 2005 9:36 pm

Does the effect is through the whole rest of life of mice A?
When you have eliminated all which is impossible, then whatever remains, however improbable, must be the truth. (Sherlock Holmes)

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Post by Dr.Stein » Mon Aug 01, 2005 12:39 am

Yes. The self reactive lymphocytes, the ones which recognize self cells as nonself, now is gone. The naïve cells now recognize self cells properly, means that they will not attack them anymore. Mouse A no longer suffers autoimmune disease.
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