embryo fusion?

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protozoan
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embryo fusion?

Post by protozoan » Tue Jul 12, 2005 6:30 pm

In my book of cytology i read that if you fuse (by pressure) 3 or more embryos it can develope to the normal individual which inherits characters from more parents. This means this individual will have for example in the cells from hand other genotype than will have cells from for example guts? (very symple told). Is this posible? Then if you tried to clon him you should clon more individuals cause you could start to clon from cells with different genotypes.( these cells would be still from that one individual that unfortunate) :shock: Then you also could get individuals which never existed but which would develope from that embryos which was before fusion. You wouldnt get his clon, but the clons of these embryos.

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Post by mith » Tue Jul 12, 2005 7:11 pm

They called it a chimera in CSI. My bio book says it can be done on mice.
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Post by protozoan » Wed Jul 13, 2005 3:48 pm

:shock: Its crazy..... Whats CSI?

By the way, i read in this book that if you fuse two somatic cells (2n or more) of plant you can get new plant with new characteristics. That hybridization can be even betwen two different species. I cannot imagine what will happen with all chromosomes of these two somatic cells. Do they work in the new karyon all or are they regulated betwen each other by some kind of way?

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Post by Poison » Wed Jul 13, 2005 4:21 pm

A new species can form with polyploidy, it is common in plants.
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Post by mith » Wed Jul 13, 2005 6:34 pm

crime scene investigation(a CBS show).
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Post by Dr.Stein » Thu Jul 14, 2005 9:38 am

We use chimera in Immunology, for instance to cure autoimmune disease.
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Post by protozoan » Sat Jul 16, 2005 6:37 pm

Dr: Stein wrote

We use chimera in Immunology, for instance to cure autoimmune disease.


How? Did you do a sheep whith human imunne system? :wink:

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Post by Dr.Stein » Sun Jul 17, 2005 2:35 am

For example, we irradiate mice A (strain-A) so they lose all their peripheral lymphocytes. Then we transfer peripheral lymphocytes (mature and educated lymphocytes) from another mouse (strain-B). This situation will induce activation of naive T cells in mice A, so they will generate a new behavior, different from the one before irradiation. This is a kind of chimera, because now in mice A environment possess cells from other strain with different origin.

Can you tell me what happened after the transfer? :wink:
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Post by protozoan » Sun Jul 17, 2005 1:46 pm

No i cannot. :D . But it would be interesting to know. Now im gonna take a long way through web to learn about imunne system. Hmmm...maybe ill find an answer. 8)

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Post by mith » Sun Jul 17, 2005 2:12 pm

Sounds like vaccination
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Post by Dr.Stein » Mon Jul 18, 2005 5:24 am

Vaccination? Hihi naah... :) In vaccination, the individual has peripheral lymphocytes. The vaccine, or to be precise the antigen, will stimulate those lymphocytes and other immune cells to respond. The acute effect is inflammatory reaction and fever. While in this case, the indivudual, mice A does not have any peripheral lymphocytes, just another leucocytes...
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Post by mith » Mon Jul 18, 2005 1:43 pm

I see, does the irradiation of mice A have any big side effects? Doesn't seem viable in humans...
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