Evolution: which came first, classical apoptosis or necrosis

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tobio1
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Evolution: which came first, classical apoptosis or necrosis

Post by tobio1 » Mon Oct 12, 2009 4:48 am

CLARIFICATION!!!!

I have to write a very short paper on the topic before Tuesday but I can't seem to find papers on the subject.
which evolved first, classical (developmental) apoptosis or injury apoptosis ( that is, injured cells try for regular apoptosis but ultimately fail end up with something in between because of lack of adequate energy)

-If you have any links or papers I would be very grateful
- i don't really have a position but I have an idea of what I could argue. To me it makes sense that injury apoptosis developed first, just as result of coming in contact with assault and because of its consequences (such as inflammation) organisms evolved a better system => apoptosis.

At the same time, most cells try to go for apoptosis and if there's not enough energy they go the necrotic-type way, so injury apoptosis could have evolved as a backbone, a safety net for apoptosis- just in case there isn't enough energy.

PLEASE offer your insights.
Thank you
Last edited by tobio1 on Mon Oct 12, 2009 7:57 am, edited 2 times in total.

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biohazard
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Post by biohazard » Mon Oct 12, 2009 6:39 am

As far as I know, necrosis, by definition, is cell death due to external factors that end cell's life prematurely. Thus, there is no necrotic pathway - necrosis is not a physiological phenomenom.

Furthermore, as long as there has been a living cell, there must have been necorisis. So I really cannot imagine how apoptosis could have emerged before necrosis.

tobio1
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Post by tobio1 » Mon Oct 12, 2009 7:56 am

_at_ biohazard: I clarified myself a bit. rather than saying necrosis, I mean injury death (an observation that injured cells try to die apoptically but can't manage (mostly due to lack of energy). I need to compare classical developmental apoptosis to this injury apoptosis. Which came first? I put my reasoning for both sides. thanks for the reply.

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